World Library  
Flag as Inappropriate
Email this Article

Calcium gluconate

Article Id: WHEBN0006146106
Reproduction Date:

Title: Calcium gluconate  
Author: World Heritage Encyclopedia
Language: English
Subject: Poison, WHO Model List of Essential Medicines, Magnesium malate, Latrodectism, Magnesium (pharmaceutical preparation)
Publisher: World Heritage Encyclopedia

Calcium gluconate

Calcium gluconate
IUPAC name
calcium (2R,3S,4R,5R)- 2,3,4,5,6-pentahydroxyhexanoate
ATC code A12
ChemSpider  YesY
Jmol-3D images Image
Molar mass 430.373 g/mol
Appearance powder
Odor odorless
Melting point 120 °C (248 °F; 393 K) (decomposes)
slowly soluble
Solubility insoluble in alcohol and organic solvents
Acidity (pKa) 6-7
NFPA 704
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 YesY  (: YesY/N?)

Calcium gluconate is a mineral supplement. It is manufactured by the neutralization of gluconic acid with lime or calcium carbonate.

It is on the health system.[1]

Medical uses


10% calcium gluconate solution (given intravenously) is the form of calcium most widely used in the treatment of hypocalcemia. This form of calcium is not as well absorbed as calcium lactate,[2] and it only contains 0.93% (930 mg/dl) calcium ion (defined by 1 g weight solute dissolved in 100 ml solvent to make 1% solution w/v). Therefore, if the hypocalcaemia is acute and severe, calcium chloride is given instead.

Magnesium sulfate overdose

It is also used to counteract an overdose of Epsom Salts magnesium sulfate,[3] which is often administered to pregnant women in order to prophylactically prevent seizures (as in a patient experiencing preeclampsia). Magnesium sulfate is no longer given to pregnant women who are experiencing premature labor in order to slow or stop their contractions (other tocolytics are now used instead due to better efficacy and side effect profiles). Excess magnesium sulfate results in magnesium sulfate toxicity, which results in both respiratory depression and a loss of deep tendon reflexes (hyporeflexia). Calcium gluconate is the antidote for magnesium sulfate toxicity.

HF burns

Gel preparations of calcium gluconate are used to treat hydrofluoric acid burns.[4][5] This is because calcium gluconate reacts with hydrofluoric acid to form insoluble, non-toxic calcium fluoride.


Calcium gluconate is also used as a cardioprotective agent in hyperkalemia. Though it does not have an effect on potassium levels in the blood, it reduces the excitability of cardiomyocytes thus lowering the likelihood of developing cardiac arrhythmias.[6]

Black Widow Spider Bites

Historically, IV calcium gluconate was used as an antidote for black widow spider envenomation, often in conjunction with muscle relaxants.[7] This therapy, however, has since been shown to be ineffective.[8][9]

Side effects

Calcium gluconate side effects include nausea, constipation, upset stomach. Rapid intravenous injections of calcium gluconate may cause hypercalcaemia, which can result in vasodilation, cardiac arrhythmias, decreased blood pressure, and bradycardia. Extravasation of calcium gluconate can lead to cellulitis. Intramuscular injections may lead to local necrosis and abscess formation.[10]

It is also reported that this form of calcium increases renal plasma flow, diuresis, natriuresis,[11][12] glomerular filtration rate,[13] and prostaglandin E2 and F1-alpha levels.[14]


  1. ^
  2. ^
  3. ^
  4. ^
  5. ^
  6. ^
  7. ^ Pestana, Carlos Dr. Pestana Surgery Notes Kaplan Medical 2013
  8. ^
  9. ^
  10. ^
  11. ^
  12. ^
  13. ^
  14. ^

See also

This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.

Copyright © World Library Foundation. All rights reserved. eBooks from World eBook Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.