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Plos Biology : Patterns of Intron Gain and Loss in Fungi, Volume 2

By Wolfe, Ken H.

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Book Id: WPLBN0003923015
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : Patterns of Intron Gain and Loss in Fungi, Volume 2  
Author: Wolfe, Ken H.
Volume: Volume 2
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Biology
Publication Date:
Publisher: Plos


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Wolfe, K. H. (n.d.). Plos Biology : Patterns of Intron Gain and Loss in Fungi, Volume 2. Retrieved from

Description : Little is known about the patterns of intron gain and loss or the relative contributions of these two processes to gene evolution. To investigate the dynamics of intron evolution, we analyzed orthologous genes from four filamentous fungal genomes and determined the pattern of intron conservation. We developed a probabilistic model to estimate the most likely rates of intron gain and loss giving rise to these observed conservation patterns. Our data reveal the surprising importance of intron gain. Between about 150 and 250 gains and between 150 and 350 losses were inferred in each lineage. We discuss one gene in particular (encoding 1-phosphoribosyl-5-pyrophosphate synthetase) that displays an unusually high rate of intron gain in multiple lineages. It has been recognized that introns are biased towards the 59 ends of genes in intron-poor genomes but are evenly distributed in intron-rich genomes. Current models attribute this bias to 39 intron loss through a poly-adenosine-primed reverse transcription mechanism. Contrary to standard models, we find no increased frequency of intron loss toward the 39 ends of genes. Thus, recent intron dynamics do not support a model whereby 59 intron positional bias is generated solely by 39-biased intron loss.


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