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Plos Biology : a Post-burst Afterdepolarization is Mediated by Group I Metabotropic Glutamate Receptor-dependent Upregulation of Cav2.3 R-type Calcium Channels in CA1 Pyramidal Neurons, Volume 8

By Bacci, Alberto

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Book Id: WPLBN0003940757
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Biology : a Post-burst Afterdepolarization is Mediated by Group I Metabotropic Glutamate Receptor-dependent Upregulation of Cav2.3 R-type Calcium Channels in CA1 Pyramidal Neurons, Volume 8  
Author: Bacci, Alberto
Volume: Volume 8
Language: English
Subject: Journals, Science, Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Biology
Historic
Publication Date:
Publisher: Plos

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Bacci, A. (n.d.). Plos Biology : a Post-burst Afterdepolarization is Mediated by Group I Metabotropic Glutamate Receptor-dependent Upregulation of Cav2.3 R-type Calcium Channels in CA1 Pyramidal Neurons, Volume 8. Retrieved from http://worldebooklibrary.org/


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Description : Activation of group I metabotropic glutamate receptors (subtypes mGluR1 and mGluR5) regulates neural activity in a variety of ways. In CA1 pyramidal neurons, activation of group I mGluRs eliminates the post-burst afterhyperpolarization (AHP) and produces an afterdepolarization (ADP) in its place. Here we show that upregulation of Cav2.3 R-type calcium channels is responsible for a component of the ADP lasting several hundred milliseconds. This medium-duration ADP is rapidly and reversibly induced by activation of mGluR5 and requires activation of phospholipase C (PLC) and release of calcium from internal stores. Effects of mGluR activation on subthreshold membrane potential changes are negligible but are large following action potential firing. Furthermore, the medium ADP exhibits a biphasic activity dependence consisting of shortterm facilitation and longer-term inhibition. These findings suggest that mGluRs may dramatically alter the firing of CA1 pyramidal neurons via a complex, activity-dependent modulation of Cav2.3 R-type channels that are activated during spiking at physiologically relevant rates and patterns.

 

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